Journal: Annals of Clinical Microbiology and Antimicrobials

Article Title: Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

doi: 10.1186/s12941-024-00678-3

Figure Lengend Snippet: Salmonella serovars applied in bacteriophage isolation

Article Snippet: Group XI , Infected by S. Typhimurium ATCC 14,028, treated by vehicle , 11.5 ± 1.2 , 7.9 , 3.7 ± 0.15.

Techniques:

Journal: Annals of Clinical Microbiology and Antimicrobials

Article Title: Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

doi: 10.1186/s12941-024-00678-3

Figure Lengend Snippet: Categorization of animals and the description of each group

Article Snippet: Group XI , Infected by S. Typhimurium ATCC 14,028, treated by vehicle , 11.5 ± 1.2 , 7.9 , 3.7 ± 0.15.

Techniques: Infection

Journal: Annals of Clinical Microbiology and Antimicrobials

Article Title: Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

doi: 10.1186/s12941-024-00678-3

Figure Lengend Snippet: Histopathological examination of liver cells. Fig a – f : Liver cells with severe degree of hydropic degeneration in all investigated groups. a : infected by S. Typhimurium ATCC 14,028, untreated, b : infected by S. Paratyphi A, untreated, c : infected by S. Typhi, untreated, d : infected by S. Typhimurium ATCC 14,028, treated by vehicle, e : infected by S. Paratyphi A, treated by vehicle, & f : infected by S. Typhi, treated by vehicle. Fig g – l : Liver cells showing mild dilation of hepatic sinusoids in all groups, some revealing adenoid pattern ( g , i & j ). Noticeable activation of Ito cells could be detected in all groups. While necrosis of some individual hepatocytes could be demonstrated in other groups ( g , i & j ) g : infected by S. Typhimurium ATCC 14,028, treated by free form, h : infected by S. Paratyphi A, treated by free form, i : infected by S. Typhi, treated by free form, j : infected by S. Typhimurium ATCC 14,028, treated by microencapsulated form, k : infected by S. Paratyphi A, treated by microencapsulated form, & l : infected by S. Typhi, treated by microencapsulated form (H&E × 400)

Article Snippet: Group XI , Infected by S. Typhimurium ATCC 14,028, treated by vehicle , 11.5 ± 1.2 , 7.9 , 3.7 ± 0.15.

Techniques: Infection, Activation Assay

Journal: Annals of Clinical Microbiology and Antimicrobials

Article Title: Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

doi: 10.1186/s12941-024-00678-3

Figure Lengend Snippet: Histopathological Examination of intestinal mucosa. a : infected by S. Typhimurium ATCC 14,028, untreated, b : infected by S. Paratyphi A, untreated, c infected by S. Typhi, untreated, d : infected by S. Typhimurium ATCC 14,028, treated by vehicle, e infected by S. Paratyphi A, treated by vehicle, & f : infected by S. Typhi, treated by vehicle. Intestinal mucosa showing marked dys-figuration of intestinal villi in all groups, marked hyperplasia of intestinal crypts in ( a , d & f ). The lamina propria in a , b , c , d & e showed significant number of normal essential cells of lymphocytes and macrophages, while marked depletion detected in f , g , h , i , j , k & l : Intestinal mucosa of phage treated groups showed normal criteria with some increase in the length of intestinal crypts in ( j ). The lamina propria harbor normal essential cell population of lymphocytes and plasma cells; in all investigated groups (H&E × 400)

Article Snippet: Group XI , Infected by S. Typhimurium ATCC 14,028, treated by vehicle , 11.5 ± 1.2 , 7.9 , 3.7 ± 0.15.

Techniques: Infection, Clinical Proteomics

Journal: Annals of Clinical Microbiology and Antimicrobials

Article Title: Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

doi: 10.1186/s12941-024-00678-3

Figure Lengend Snippet: Average body weight gain of albino mice and bacterial viable count of Salmonella serotypes in liver of animals among the groups

Article Snippet: Group XI , Infected by S. Typhimurium ATCC 14,028, treated by vehicle , 11.5 ± 1.2 , 7.9 , 3.7 ± 0.15.

Techniques: Infection